Team Kakashi was sent on a mission to rescue Gaara from Akatsuki. When Tsunade began to worry that they might have problems, she sent Team Guy as back-up. On their way to a rendezvous point, they were attacked by Kisame Hoshigaki. Kisame was quite angered that Guy didn't remember him from their fight in Part I. Kisame soon captured Lee, Neji, and Tenten, but by opening the sixth gate, Guy ended the fight quickly, and they moved on. Once Kakashi's team arrived after them, the two squads found out that there was a barrier on the Akatsuki headquarters, something Team Guy volunteered to take down. They split up and removed seals spread out across the area, bringing down the barrier but triggering a trap: they were attacked by clones of themselves. When they were about to be defeated, Lee figured out how to beat the clones - by being stronger than when they met them. With that, Lee uses a new technique to defeat his clone. Later on, they reunited with Team 7 and, once Gaara was revived, they headed back home. As they left, Guy was carrying Kakashi for a piggyback-ride. Lee, thinking it was training, told Neji to get on his back so that they might race back to Konoha, but was forcefully rejected.When news reaches Konoha of Sasuke Uchiha's crimes against other villages, Lee and the rest of the Konoha 11 decide they should eliminate Sasuke themselves before he can involve Konoha in a war. So that Sakura can inform Naruto of their decision, Lee, Kiba, and Sai escort her to the Land of Iron. When they locate him, Sakura tells Naruto that she loves him, surprising Lee. This does not convince him to give up his own search for Sasuke, so they leave without another word. Sakura then asks her escorts to help her find Sasuke. When they near his location, Sakura tries to knock them out so she can face Sasuke alone. Sai stops her, so Sakura convinces Lee and Kiba that he is a traitor. While they try to detain him, she succeeds in knocking them out. After Sakura and the rest of Team 7 meet with Sasuke, they revive Lee and the others and return to Konoha. Lee is later seen with the rest of the Konoha 11, hearing Naruto's decision to take responsibility for Sasuke.
